Vernonia amygdalina - an overview | ScienceDirect Topics Vernonia amygdalinaare green with a char acteristic odour and bitter taste. injected with insulin [ ]. (Pinto and Rivlin, 1999; Li and Schellhorn, 2007). It is utilized as a food ingredient as well as supplement for the treatment and management of type 2 diabetes (T2D). Effect of Ethanolic Root and Twig Extracts of Vernonia ... J Sci Res Dev. INTRODUCTION edicinal plants have provided very interesting areas of research in the history of man. prevent sickness, support liver functions, manage diabetes, detoxify the body - the list of benefits goes on and on. The Glycaemic Effects of Vernonia amygdalina and V. tenoreana with Tolbutamide in Rats and the Implications for the Treatment of Diabetes Mellitus. In the Mahale Mountains of Tanzania is a small shrub, Vernonia amygdalina, known as bitter leaf. Vernonia. Vernonia Amygdalina Research Papers - Academia.edu hypertension and diabetes locally as a result of the inability of the synthesized drugs to completely eradicate the ailments and also with the attendant side effects attached . PDF PHYTOCHEMICAL AND PHARMACOLOGICAL PROPE OF Vernonia ... Medicinal plants are precursors for thesynthesisofusefuldrugs[]andareusedinthemanage-ment of several disorders including diabetes mellitus []. [PDF] Anti-diabetic activity and mineral elements ... • Fatty acids and phytols are involved in anti-diabetic mechanism of V. amygdalina. Bitter leaf is a common plant in the South-Eastern part of Nigeria. Methanol, aqueous, dichloromethane, n-hexane, alpha amylase, alpha glucosidase Introduction Diabetes mellitus is a chronic metabolic disorder that continues to present as a major health problem worldwide. Introduction Diabetes mellitus is a diseased condition characterized by high glucose levels caused by an absolute or relative deficiency of insulin, a special sugar regulatory hormone produced by the pancreas, a gland in the body. BITTER LEAF Bitter leaf is botanically known as Vernonia amygdalina Del. ABSTRACT: Vernonia amygdalina (VAM) is a medicinal plant that has been use traditionally in the management of diseases especially diabetes. In the study, researchers examined the potency of old and young leaf extracts of Vernonia amygdalina in the treatment of diabetes in rats. In Malaysia, about 2.6 million adults were diagnosed with diabetes and most of them turn to herbal medicine for treatment. 2020; 2(3):78-85. Srinivasan K, Viswanad B, Asrat L, Kaul CL, Ramarao P. Combination of high-fat diet-fed and low-dose streptozotocin-treated rat: A model for type 2 diabetes and . Sepici A, Gurbuz I, Cevik C, et al. Given widespread use of Vernonia amygdalina and in the light of the consideration that her-drug interaction is an important safety Vernonia amygdalina has been a known food and medicinal plants used in Asia and Africa (West Africa) due to its pharmacological effects (antioxidant, anti-diabetes, anti-inflammatory, anticancer, anti-malaria, and among others). Vernonia amygdalina contains biologically-active compounds known as coumarins, flavonoids, anthraquinone, phenolic acids, saponins, sesquiterpenes, xanthones, terpenes, steroids, lignans and edotides. Characterization and Evaluation of Vernonia amygdalina Extracts for its Antidiabetic Potentials Characterization and Evaluation of Vernonia amygdalina Extracts for its . Vernonia amygdalina leaves were collected from V. amygdalina is well known as a medicinal plant with several uses attributed to it, including for diabetes, fever reduction, and recently a non-pharmaceutical solution to persistent fever, headache, and joint pain associated with AIDS (an infusion of the plant is taken as needed). Sepici A, Gurbuz I, Cevik C, et al. ABSTRACT. It affects the metabolism of carbohydrate, fat, proteins, as well as water. Vernacular names COUNTRY LANGUAGE/TRIBE VERNACULAR NAME Ghana Adangme Agba, Tatsho, Akpa, Agoaflu Akan Bowin Twi Awonwone Fanti Bowene Nzema Ayeanwonle Ewe Gbo, Gboti,Gbotsi Dagbanli Bieningira Hausa Shiwaka… Given widespread use of Vernonia amygdalina and in the light of the consideration that her-drug interaction is an important safety Therefore, the inhibition of α‐amylase, α‐glucosidase and ACE, coupled with the antioxidant activities of bitter leaf phenolic‐rich extracts, could be a possible mechanism through which Vernonia amygdalina exert its antidiabetes and antihypertension properties. This study evaluated the effect of leaf extracts of this plant on glucose utilization in 3T3-L1, C 2 C 12 muscle, and Chang-liver cells. This review will stimulate further research on V. amygdalina and diabetes treatments. more. Studies have shown that various extracts of V. amygdalina have possessed hypoglycemic effect on alloxan monohydrate and streptozotocin induced diabetic animals (Nwanjo, 2005; Igbakin and Oloyede, 2009). Keywords: Vernonia amygdalina, Gene expression, Gluconeogenesis, Pentose phosphate patheway, Diabetes mellitus, Mechanism of anti-diabetic action * Correspondence: dratangwho@gmail.com 1School of Pharmaceutical Sciences, Universiti Sains Malaysia, Minden 11800, Penang, Malaysia 3Department of Biochemistry, College of Medical Sciences, University of Phytochemical screening and GC-MS analysis were carried out while 25 male albino wistar rats (137-223 g) were used to evaluate the andiabetic activity. Hypoglycemic effects of myrtle oil in normal and alloxan - diabetic rabbits. According to a study published in the West African Journal of Pharmacology Drug Res., Bitter Leaf could be effectively used against drug resistant microorganisms. Traditional Medicine- African Bitter Leaf |Vernonia amygdalina. J Diabetes Clin Res. INTRODUCTION The human population worldwide seems to be in the midst of an epidemic of diabetes. . Formulation and development of hesperidin loaded solid lipid nanoparticles for diabetes; Molecular properties of polyvinyl alcohol/ sodium alginate composite; Utilization of palm oil mill effluent and clindamycin for optimization of polyhydroxy [r] alkanoates production (Asteraceae) is one of the plants commonly used for the treatment of diabetes in Africa. The plant is a shrub with moderate canopies occurring in open, regrowth forest locations; it is often raised . • The functional role of V. amygdalina in nutrition and medicine has been substantiated. Journal of Integrative Medicine, 2017, 15(4): 302-309. This study focused on the in-vitro inhibitory activity of Vernonia amygdalina leaf grown in . Hot infusion of V. amygdalina leaves was incubated with rat brain tissues for 2 h in the presence of glucose . KEYWORDS: Antidiabetic drug, fasting blood sugar, Metformin and Vernonia amygdalina, DINTRODUCTION Methods: A search was made at Nnewi, South-East Nigeria for known diabetes who use Vernonia amygdalina either as their sole or supplementary antidiabetic. Some of its species; Vernonia cinerea and Vernonia anthelmintica are available in India. 2. As of Thus, this study confirms the anti-hyperglycaemic effect of Vernonia amygdalina cultivated in Enugu and recommends its consumption for the control and management of diabetes. Vernonia amygdalina grows Key words: Vernonia amygdalina, ethnomedicine, diabetes, alloxan. Some of these nutrients and . Vernonia amygdalina, Alloxan monohydrate, Glucose, Histopathology, Glucometer INTRODUCTION Diabetes mellitus is a disease condition characterized by high blood glucose levels caused by an absolute or relative deficiency of insulin. Vernonia amygdalina, a woody shrub that can grow up to 5 m tall, belonging to the family of Asteraceae, is native to Nigeria (West Africa) and is widely grown in Africa (Farombi & Owoeye 2011). This study aimed to validate the antidiabetic effects of VA leaf fraction (VALF) in a unique T2D rat model. The presence of these compounds in bitter leaf makes it viable for it to be used for controlling and treating diabetes. V. amygdalina leavesarerichinfats, proteins, fibres, minerals, amino acids, carbohydrate, and vitamins [6,7]. Effects of Vernonia Amygdalina and Chlorpropamide on Blood Glucose Abraham A.A. Osinubi Department of Anatomy, College of Medicine, University of Lagos, Idi-Araba, Lagos, Nigeria. No doubt, this accounts for its use in folkloric medicine for treatment of diseases such as eczema, measles and anemia [6]. European Scientific Journal October 2013 edition vol.9, No.30 ISSN: 1857 - 7881 (Print) e - ISSN 1857- 7431 200 Keywords: Vernonia amygdalina,biochemical indices, diabetes and Wistar rats The phytochemical studies revealed that this plant is enriched with proteins, fats, fibres, amino acids, minerals, • Cardiovascular Effects of Vernonia amygdalina in Rats and the Implications for Treatment of Hypertension in Diabetes. Antioxidants defend your cells against oxidative stress and help prevent metabolic disorders like diabetes, cancer, and coronary heart disease. [2][3] These leaves are exported from several African countries . Vernonia amygdalina (VAM) is a medicinal plant that has been use traditionally in the management of diseases especially diabetes. and antioxidant activities of Vernonia amygdalina delile and Baccharoides tenoreana olive in alloxan-induced hyperglycemic rats Samuel Chijioke Attama1, Patrick Emeka Aba1*, Chinwe Uchechukwu Asuzu2 and Isaac Uzoma Asuzu1 Abstract Background: Vernonia amygdalina is a bitter culinary vegetable known to possess anti-diabetic principle. Vernonia Amygdalina. r. Ihekweazu's skepticism over Dr. Obyo Nelson's claim of a diabetes cure based on Vernonia amygdalina was really well articulated. Capsules, Vernonia amygdalina, Diabetes, Combination with standards. Vernonia amygdalina Del. J Diabetes Clin Res. Phytochemical screening and GC-MS analysis were carried out while 25 male albino wistar rats (137-223 g) were used to evaluate the andiabetic activity. Ocimum gratissimum and Vernonia amygdalina in Alloxan-Induced Diabetic Rats. Vernonia amygdalina root extract to manage hyperglycemia. Vernonia amygdalina is also found in Asia, and 2015; 6(7):223- 230. Bitter leaf greens are used in the form of vegetable eaten to promote and enhance the digestive tract to do its job. Its extreme bitterness successfully keeps most indigenous animals away, although introduced domesticated goats appear unable to identify the risks; consequently, another common name for this plant is "goat killer." Polyphenols-rich Vernonia amygdalina shows anti-diabetic effects in streptozotocin-induced diabetic rats VA possesses antihyperglycemic effect, most probably through increasing GLUT 4 translocation and inhibiting hepatic G6Pase. Forty male Wistar rats were divided into two groups A and C; the former served as negative control group received normal saline, while the later was the diabetic group. Although there are quite several synthetic drugs used in managing this disease, however, due to their side effects, the use of natural sources is imperative. Moreover, the extracts from V. amygdalina leaves possess several secondary metabo-lites which include flavonoids, polyphenols, saponins, tannins, and terpenoids [7]. Diabetes was induced using Alloxan Monohydrate. It is widely used as a daily green vegetable or herb to treat malaria and diabetes. When the blood glucose level was tested using the glucose oxidase kit, it was observed that the group of animals administered with a combination of Vernonia amygdalina extract and metformin shows significant decrease in the blood glucose level compared to the diabetic control and group of animals . The medicinal benefits of the bitter leaf ( Vernonia amygdalina) include: Antioxidant properties The bitter leaf plant is rich in plant compounds that function as antioxidants. EFFECTS OF VERNONIA AMYGDALINA AND CHLORPROPAMIDE ON BLOOD GLUCOSE Medical Journal of Islamic World Academy of Sciences 16:3, 115-119 115 *From Department of Anatomy, College of Medicine, University of Lagos, Idi-Araba, Lagos, Nigeria. management and alleviation of diabetes and its complications (Haq 2004; Remuzzi, Macia & Ruggenenti 2006). 2017, Article . The study titled "Efficacy of a syrup formulated from combined extracts of Vernonia amygdalina and Musa paradisiaca for the management of type 2 diabetes" was published in African Journal of . DM is one of the world's leading causes of death, with Vernonia amygdalina among Immune System Boost Vernonia amygdalina is a shrub that has been commonly known as bitter leaf due the bitter taste of the leaves. have found good use in Vernonia amygdalina (Linn), a herb used in lowering blood glucose in diabetic condition[15] also nifedipine is readily prescribed for significant number of hypertensive patients. The plant extract of Vernonia amygdalina (bitter leaf) was administered to the rats orally at concentrations of 2%, 4%, 6%, 8% and 10% before meals for 5, 10 and 15 days respectively after which, blood samples were collected from the animals and analyzed for glucose levels using enzymatic methods. Vernonia amygdalina (Family: Compositae) is a soft wooded shrub that traditionally used to treat diabetes. This study aimed to assess the histomorphological and glycaemic effects of the ethanolic leaf extracts of Vernonia amygdalina (VA) and Gongronema latifolium (GL) on the testis of alloxan-induced diabetic Wistar rats. The common name is bitter leaf. amygdalina is a plant that originates from tropical west Africa; it bears the common name Bitter leaf, and as the name implies, virtually every part of the plant is known to possess a distinct bitterness in it. Hypoglycemic effects of myrtle oil in normal and alloxan - diabetic rabbits. 2020 Volume 2, Issue 3 remedies such as herbs for their daily needs and about 855 traditional medicines include crude plant extracts [6]. leaves to STZ- induced diabetic rats are shown in Figure 1.The animals lost 5 - 10 g (2-4%) body weight and a corresponding 16.5 mmol/L (75.5%) rise in blood glucose concentration upon induction of diabetes. hypertension and diabetes locally as a result of the inability of the synthesized drugs to completely eradicate the ailments and also with the attendant side effects attached . 1. Introduction Diabetes mellitus is a diseased condition characterized by high glucose levels caused by an absolute or relative deficiency of insulin, a special sugar regulatory hormone produced by the pancreas, a gland in the body. V. Amygdalina is one of the widely consumed leaf vegetables in Nigeria and well known as a medicinal . African tea leaf (Vernonia amygdalina; VA) extract had been investigated considered for diabetes therapy due to its ability for helping pancreatic cells to synthesize insulin, as well as protecting them from degenerative and . diseases such as diabetes mellitus, breast cancer, hypertension, etc. Key words: Vernonia amygdalina, ethnomedicine, diabetes, alloxan. Vernonia amygdalina hasan anti-hyperglycaemic effect and the ethanol extract was more effective than the aqueous extract in lowering blood sugar concentration in rats. The ability of Vernonia amygdalina to stimulate glucose uptake as well as ameliorate glucose-induced oxidative stress and proinflammation were investigated in rat brain. Medicinally, this plant is used to treat illnesses ranging from diabetes and hypertension to several bacterial, parasitic and . The Bitter Leaf plant is a good source of dietary fibers, proteins, various minerals like calcium, magnesium, potassium, sodium, manganese, iron, zinc, and copper. Brain glucose uptake is usually reduced in type 2 diabetes owing to downregulation of brain glucose transporters. Bitter leaf belongs to the Asteraceae family in the large genus Vernonia. In the study, which lasted 4 weeks, 56 diabetic rats were divided into nine groups as follows: Group 1 (normal control) - rats not induced with diabetes. Vernonia Amygdalina Del. The Glycaemic Effects of Vernonia amygdalina and V. tenoreana with Tolbutamide in Rats and the Implications for the Treatment of Diabetes Mellitus. destroyed in diabetes mellitus and consequently may be responsible in full or in part for the antihyperglycemic effect of Vernonia amygdalina. These phytochemicals might be responsible for its anti-diabetes . Vernonia amygdalina is an edible plant of the Asteraceae family. Vernonia amygdalina or locally known as bitter leaf is believed by the local people and traditional inhaler to reduce blood glucose level. Vernonia amygdalina is a shrub common in tropical . 2. This study lends support to the claim by herbalists of Plateau and Nassarawa States that Vernonia amygdalina may have an antidiabetic effect in diabetes mellitus. • Water is the best medium for antioxidant recipe of V. amygdalina leaves. Diabetes continue to threaten global health especially type II which is responsible for majority of the disease mortality. Type diabetes mellitus describes a condition of fasting hyperglycemia that occurs despite the availability of insulin []. It is of the African origin. A total of ten volunteers comprising, eight females and two males were recruited. Oral administration of CCl(4) at a dose of 1.2g/kg body weight 3 times a week for 3 weeks significantly induced marked hepatic . Du-Bois Asante, Emmanuel Effah-Yeboah, Precious Barnes, Heckel Amoabeng Abban, Elvis Ofori Ameyaw, Johnson Nyarko Boampong, Eric Gyamerah Ofori, Joseph Budu Dadzie, " Corrigendum to "Antidiabetic Effect of Young and Old Ethanolic Leaf Extracts of Vernonia amygdalina: A Comparative Study" ", Journal of Diabetes Research, vol. The animals were randomly divided into five groups (n=5). Uduak Akpan Okon, Idorenyin Udo Umoren. Diabetes Mellitus (DM) is a metabolic disease that occurs due to abnormalities in insulin secretion and/or action. It is commonly known as bitter leaf due to its bitter taste, in Nigeria and in tropical African regions as well as in South Africa [25]. Diabetes has been characterized by transmuted lipids, hyperglycemia, proteins, and carbohydrates metabolism that can affect the quality of life. The bitter leaf plant is ubiquitous throughout Africa, where it has long been used as a cooking ingredient. • Water is the bitter leaf is a group of metabolic diseases by! 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