CNN reports on researcher Michael Worobey, "who specializes in tracing the genetic evolution of viruses," who has now found "considerable evidence that the virus arose in an animal, and did not start circulating until the end of 2019."One case especially stood out — that of a 41-year-old accountant who allegedly got sick on December 8, 2019 and who had no connection to the market. Received 22 February, 2020. 17 Feb, 2018, 09.13 AM IST. It is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Apologize for the long read, but appears to come from a credible source. Coronaviruses (CoVs) are enveloped, nonsegmented positive-sense RNA viruses. COVID-19 was unknown before the outbreak began in Wuhan, China, in December 2019 [3] [6] [7]. More than 25,000 people have now died from the fast-moving. ⛷ | Installation of lift at ski resort in Kanazawa before ... It's a coincidence in space and time. The only mammal with hard, plate-like scales, it looks something like a badger in chainmail - and at the merest hint of danger, the pangolin simply roles up into a tight ball that is nearly . Abstract: To treat the cause of a disease and not only its effects is of the utmost importance; hence, we need to know the origin of this pandemic of COVID-19, in order to be able, if possible, to prevent an event of such a nature and magnitude in the future, and to be able to avoid every sort of abuses to humanity, as it is happening right now. 03-30-2020, 01:33 PM CatTX : 2,350 posts, read 1,225,634 times Reputation: 9248. design@pagepanther.co.za 2020-03-16T11:27:03+00:00 #EachforEqual - International Women's Day 2020 "An equal world is an enabled world" is one of the International Women's Day mantras and speaks to the purpose of the day and the cause that it aims to raise awareness for. Truth is stranger than fiction: GRAPHENE OXIDE ... Coronavirus disease 2019 (COVID-19) is a declared global pandemic. How to start and stay on the Mediterranean diet | CNN 2020:2020.02.19.950253. Before the arrival of full-scale winter, lift installation work was carried out at the ski resort in Kanazawa . Since the initial reports of coronavirus disease 2019 (COVID-19) outbreak in Wuhan, China on 30 December 2019 [1,2], SARS-CoV-2 has been spreading worldwide and, as of 15 July 2021, there have been 188.13 million confirmed infections and 4.06 million deaths [].This was the reason that SARS-CoV-2 epidemic was declared a global pandemic by World Health Organization (WHO) on 11 March 2020 []. Last year, the number of visitors on Saturdays and Sundays was less than usual due to the influence of the new Corona, but this year we expect 4 visitors. COVID-19 stands for CO -rona- VI -rus D -isease and the year it was first discovered which was in 2019. Given new evidence on the B.1.617.2 (Delta) variant, CDC has updated the guidance for fully vaccinated people.CDC recommends universal indoor masking for all teachers, staff, students, and visitors to K-12 schools, regardless of vaccination status. Begin at the Beginning: The Malayan Pangolin Hypothesis ... Sometimes that transferred virus will cause a respiratory disease that passes rapidly from one person to another. The first transmissions of COVID-19 from animals to humans are said to have taken place at an animal market in Wuhan, China. A hindrance to this development is the vast amount of misinformation present due to scarcely sourced manuscript preprints and social media. Peter Daszak Eco-Fascist Who Orchestrated Global Pandemic Why the coronavirus puzzle still hasn't been solved. INTRODUCTION. The genomic average dS value between SARS-CoV-2 and GD Pangolin-CoV is 0.469, which is comparable to that between humans and mice (0.5) , and the dS value between SARS-CoV-2 and GX Pangolin-Cov is even larger (0.722). By 1983 virologists had identified a novel pathogen they would call Human Immunodeficiency . Jackson Ryan May 28 2020. 17 February is celebrated as World Pangolin Day. (PDF) Understanding COVID-19 transmission, health impacts ... Prelims Practice Questions 03-01-2018. Protein Structure and Sequence Reanalysis of 2019-nCoV Genome Refutes Snakes as Its Intermediate Host and the Unique Similarity between Its Spike Protein Insertions and HIV-1. Repurposing of clinically approved drugs for treatment of ... An outbreak of serious pneumonia disease was reported in Wuhan, China, on 30 December 2019. Then . The scale of these measures suggests that we should perhaps consider the difference in the neutral evolving site rather than the . The International Committee on Taxonomy of Viruses gave . Due to genetic similarities, concern about the infection of non-human primates (NHPs) and the establishment of a sylvatic cycle has grown in the Americas. SARS-COV-2 Laboratory Leak Hypothesis Guest Post by Andrew Tuntable, Ph. Bullet points here addressed are: 1) To have . According to the International Union for Conservation of Nature (IUCN), more than a million pangolins were poached in the . D. Email: atuntable@gmail.com Twitter: @atuntable SARS-COV-2 Laboratory Leak HypothesisThe Lab Leak HypothesisThe Importance of the HypothesisBeyond Reasonable DoubtSummary of the EvidenceGeographyNatural precursorsLaboratory LeaksChimeraFurin Cleavage Site2013 Sick Bat Guano MinersDatabase Removal and ObfuscationSick WIV . Coronavirus disease 2019 (English) - who (WHO) Coronavirus (COVID-19) (English) - National Institutes of Health (NIH) Coronavirus Disease 2019 (COVID-19) (English) - Center for Disease Control and Prevention (CDC) Modeling 2019-nCoV (English) - Johns Hopkins University engineeringJohns Hopkins University Whiting School of Engineering Public health Focus on plants. January 03, 2018. . Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), an emerging zoonotic virus that has achieved extensive community spread among humans. Instead there is likely to be an intermediate host. Of the total recorded seizures, 30 seizures were recorded in 2018, 49 in 2019 and 38 in the 8 months of 2020 (January 2020 - August 2020) ().Comparing only the reported seizures from the COVID-19 lockdown months (March-August) of 2020 with the same period of 2018 and 2019, there were 29 pangolin seizures reported in 2020, 19 in 2019 and 8 in 2018, indicating a statistically significant . All dating studies involving SARS-CoV-2 are problematic. Other SARS-CoV-like CoVs similar to Pangolin-CoV were bat SARSr-CoV ZXC21 (85.65%) and bat SARSr-CoV ZC45 (85.01%). This could be due to: (i) a cross-reactivity of immune responses between FCoV and SARS-CoV-2, most likely to the nucleocapsid protein; or (ii) a SARS-CoV-2-like virus circulating in cats in Istanbul. The novel coronavirus origin was attributed to two animals, the bat and the pangolin. The percentages listed in the True Color Image menu refer to the visibility based on cloud cover over the Chesapeake Bay water surface: 0% = zero visibility due to near total cloud cover. bioRxiv 2020; 14 February: 2020.02.08.939660. However, knowledge and attitudes of TCM practitioners about pangolin scale medicines are also crucial for regulating pangolin scale trade, since this stakeholder group has the potential to influence consumer behaviours and decide or guide consumption (Doughty et al., 2019; Tan & Freathy, 2011). The COVID-19 pandemic, also called the coronavirus pandemic, is a current pandemic of coronavirus disease 2019 (COVID-19). It is not the precursor of SARS-CoV-2, but comparison of viral genome sequences provides further evidence that the virus currently infecting humans was not produced in a laboratory. The amino acid phylogenetic tree showed that the S1 protein of Pangolin-CoV is more closely related to that of 2019-CoV than to that of RaTG13. Understanding COVID-19 transmission, health impacts and mitigation: timely social distancing is the key also known as the coronavirus pandemic, is an ongoing global pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Public Awareness of the Protection and Legal Status of Pangolin. 2018.03.01.1 2018.03.01.2 2018.03.01.3 . Consider the following statements. The causative agent was soon identified as a novel coronavirus 1, which was later named SARS-CoV-2.Case . Likewise, other pangolin-CoV isolated from 17 of 25 Malayan pangolins showed 100%, 98.6%, 97.8% and 90.7% amino acid identity with SARS-CoV-2 in the E, M, N and S proteins, respectively. In fact, a scientist from UK as reported by Guardian (2004) and supported by the United Nation report (UN, 2019) estimated 1 million species will extinct by 2050. Hua-Hao Fan, Li-Qin Wang, Wen-Li Liu, and Xiao-Ping An contributed equally to the work. Repurposing of clinically approved drugs for treatment of coronavirus disease 2019 in a 2019-novel coronavirus -related coronavirus model. Repurposing of clinically approved drugs for treatment of coronavirus disease 2019 in a 2019-novel coronavirus -related coronavirus model. Lancet Infect. Researchers presently presume this coronavirus, SARS-CoV-2, began in a bat and some way or another jumped to another creature, conceivably the pangolin, which at that . WHO's Director-General characterized COVID-19 as the first pandemic to have been caused by a coronavirus while still stating that they had never before seen a pandemic that can be controlled, at the same time. The new analysis suggests "the pangolin as a missing link . The world has experienced several epidemics posing serious threat to global public health, including the 2002 severe acute respiratory syndrome (SARS) epidemic that caused 800 deaths out of about 8 000 cases, the 2009 H1N1 pandemic with 18 500 deaths, the 2012 Middle East respiratory syndrome (MERS) epidemic that caused 800 deaths out of 2 500 cases, the 2014 Ebola outbreak with 28 616 cases . 2020年9月 ,英國某研究項目发现,2019年年底SARS-CoV-2或已在全球传播,并且仍在反复发生突变以不断适应其人类宿主。. Pangolins are the only mammals that are covered in scales, which are made of keratin—just like our hair and finger nails. Then, there are a lot of lists of animals will be disappeared in the very near future worldwide. The outbreak started in Wuhan, Hubei, China, in December 2019.The World Health Organization (WHO) called it a pandemic on 11 March 2020. . But there's an idea that another animal may have transported the virus from bats into humans. Received 22 February, 2020. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was capable to infect domestic and captive mammals like cats, tigers and minks. Therefore, we reinvestiga … A review Paper published early 2019 in an open access journal, by researchers from the Wuhan Institute of virology, clearly predicted that bat-borne CoVs would re-emerge to cause the next disease . 2003) and MERS-CoV in 2012 (Zaki et al. 5, 7 Large droplet transmission and contact transmission are the two main routes of human-to-human . Previous studies have dated the most recent common ancestor (MRCA) between SARS-CoV-2 and its close relatives from bats and pangolins. D. Email: atuntable@gmail.com Twitter: @atuntable SARS-COV-2 Laboratory Leak HypothesisThe Lab Leak HypothesisThe Importance of the HypothesisBeyond Reasonable DoubtSummary of the EvidenceGeographyNatural precursorsLaboratory LeaksChimeraFurin Cleavage Site2013 Sick Bat Guano MinersDatabase Removal and ObfuscationSick WIV . As a matter of fact, a year before the virus jumped bat-ship and flooded the world, researchers had already predicted the 2019 outbreak in China. Some forums can only be seen by registered members. We tested whether serologically proven prior DENV infection diagnosed in September-October 2019, before the coronavirus disease 2019 (COVID-19) pandemic, reduced the risk of SARS-CoV-2 infection and clinically apparent COVID-19 over the next 13 months in a population-based cohort in Amazonian Brazil. SARS-COV-2 Laboratory Leak Hypothesis Guest Post by Andrew Tuntable, Ph. In 1981, doctors in New York and Los Angeles saw healthy young men sicken and die within months, their immune systems apparently destroyed. In 2019, a new coronavirus disease (COVID-19) was detected in China. Pangolin was developed to implement the dynamic nomenclature of SARS-CoV-2 lineages, known as the Pango nomenclature. By Vincent Racaniello A coronavirus related to SARS-CoV-2 has been isolated from Malayan pangolins illegally imported into Guangdong province. The Delta variant is a variant of SARS-CoV-2, the virus that causes COVID-19. Chin Med J 2020;133:1051-1056. doi: 10.1097/CM9.0000000000000797. Overweight - The Single Risk Factor in Covid Mortality Rate. There is an urgent need for sensitive diagnostic testing implementation to control and manage SARS-CoV-2 in public health laboratories. This literature review aims to presents accredited and the most current studies . That is over a month sooner than specialists noted cases in Wuhan, China, which is in the Hubei region, toward the finish of December 2019. There are two important sequences in the viral spike glycoprotein . Some patients got infected through only asymptomatic contact. It was first detected in India in late 2020. An outbreak of coronavirus disease 2019 (COVID-19) caused by the 2019 novel coronavirus (SARS-CoV-2) began in the city of Wuhan in China and has widely spread worldwide. On April 4, 2021, a 5-year-old male Malayan tiger (Panthera tigris jacksoni) at the Virginia Zoo (Norfolk, VA, USA) began exhibiting lethargy, labored breathing, coughing, intermittent upper respiratory sounds, hyporexia, and mucoid nasal discharge.On April 7, another 5-year-old male Malayan tiger began experiencing labored breathing, cough, clear nasal discharge, and hyporexia. . Zhang T, Wu Q, Zhang Z. Pangolin homology associated with 2019-nCoV. Evolving epidemiology and transmission dynamics of coronavirus disease 2019 outside Hubei province, China: a descriptive and modelling study. The deaths set off a frantic search for the culprit. While this manuscript was under review, two similar preprint studies found that CoVs in pangolins shared 90.3% [ 10 ] and 92.4% [ 11 ] DNA identity with SARS-CoV-2, approximating the 91.02% identity to SARS-CoV-2 observed here and . That means, before reaching humans, the virus could have passed from bats to the pangolin, the most illegally traded animal in the world. bioRxiv. It should be made clear that the source of COVID-19 is still unknown, despite much of our media claiming the source to be the infamous wet market in Wuhan and the UN subsequently calling to end all of such markets 1. An outbreak of coronavirus disease 2019 (COVID-19) caused by the 2019 novel coronavirus (SARS-CoV-2) began in the city of Wuhan in China and has widely spread worldwide. Wahba L, Jain N, Fire AZ, Shoura MJ, Artiles KL, McCoy MJ, et al. 2012).SARS-CoV-2, which causes the COVID-19 disease in humans, spread in early 2019 leding to a pandemie. There are two important sequences in the viral spike glycoprotein . Tracing the source of the COVID-19 pandemic is proving to be a gargantuan task. Quote: . The Delta variant was named on 31 May 2021 and had spread to over 179 countries by 22 November 2021. Genome sequencing of the virus isolated from a patient's lower respiratory tract on 10 January 2020 confirmed . If You Want Pandemics, Build Factory Farms. 17 Feb, 2018, 09.13 AM IST. There are multiple parameters of the clinical course and management of the COVID-19 that need optimization. Pangolin assigns lineages to query sequences as described in Rambaut et al 2020. In this study, neotropical . Chin Med J 2020;133:1051-1056. doi: 10.1097/CM9.0000000000000797. The RBD of the S protein of pangolin-CoV was similar to that of SARS-CoV-2, with only one difference in a noncritical amino acid (Xiao et al. Jansen said that a zoonotic disease such as nCoV-2019 could even survive in a dead pangolin, "as long as the environment is liquid and moist and the animal hasn't dried out completely. Dis. Here, I present dating results for the first time from a large . If such a disease has an incubation period that gives the person a few days before they feel ill, we have the perfect storm for a pandemic. For the bats, two . 100% = excellent visibility due to clear conditions. The majority of the respondents were aware that pangolins are protected animals in China, but only 19.47% (381/1,957) could identify pangolins as Category II state-protected animals ().Only 0.20% (4/1,957) thought that pangolins were common, unprotected wild animals, and 4.80% (94/1,957) were not sure if the pangolin was a . 1. So whenever you say COVID-19, you are specifically talking about the disease. 这项研究名为"Emergence of genomic diversity and recurrent mutations in SARS-CoV-2",发表在国际医学期刊《感染、遗传学和进化》(Infection, Genetics and . Video: Eye of the Pangolin User Name: Remember Me: Password : Please register to participate in our discussions with 2 million other members - it's free and quick! The coronavirus disease-19 (COVID-19) is an infectious disease caused by the most recently discovered coronavirus. That means an emphasis on plants: fruits, vegetables, grains, nuts and seeds. On December 14, 2020, the United Kingdom reported a SARS-CoV-2 variant of concern (VOC), lineage B.1.1.7, also referred to as VOC 202012/01 or 20I/501Y.V1. 17 February is celebrated as World Pangolin Day. 04/01/2019 Why smart people are more likely to believe fake news. It is not the precursor of SARS-CoV-2, but comparison of viral genome sequences provides further evidence that the virus currently infecting humans was not produced in a laboratory. Eat a lot of veggies and use all kinds and colors to get the broadest range of nutrients . Within the RBD, we further found . Dr. Michael Zapor Being an infectious diseases physician, research microbiologist, and former deputy commander of the Walter Reed Army Institute of Research (which is in the business of identifying, researching, and mitigating infectious disease threats), I thought I'd make a few comments about Coronavirus Disease-2019. Since the middle of December 2019, a new type of coronavirus infection has been prevalent in Wuhan, China, and has rapidly spread to a large area. Zhang, J. et al. Most of the patients had a history of visiting Hubei Province or contacting with people who had ever stayed in or passed by Hubei Province or were exposed to symptoms. called SARS-CoV-2. It is not a full match suggesting that the disease did not jump straight from the two dead pangolins to humans. As a matter of fact, a year before the virus jumped bat-ship and flooded the world, researchers had already predicted the 2019 outbreak in China. The disease it causes is dubbed COVID-19 formerly called 'Coronavirus disease 2019'. Two major reasons why viruses can spread so fast now: population increase and air travel. SARS-CoV-2 is the third human coronavirus (CoV) responsible for severe respiratory syndrome that emerged in the last 20 years, the two previous ones being SARS-CoV in 2002 (Drosten et al. Background . It allows a user to assign a SARS-CoV-2 genome sequence the most likely lineage (Pango lineage) to SARS-CoV-2 query sequences. Remember that it all started in Wuhan, and this was the first pilot sample city in the world to do the 5G technology trial in late November 2019. 2020). A pandemic is essentially a disease epidemic that has spread across a large region, throughout either multiple continents or worldwide. And that is where the pangolin comes in. Ejiao is a traditional medicine made from Pangolin's skin. They are toothless, nocturnal, live in burrows and feed mainly on ants and termites. Therefore, we reinvestigated published data from pangolin lung samples . True; many of the first cases had links to the wet market in Wuhan. A 2019 study found that of viruses originating from the five most common mammalian sources — primates, rodents, carnivores, ungulates and bats — those from bats are the most virulent in humans. That case goes back to Nov. 17, 2019. A review Paper published early 2019 in an open access journal, by researchers from the Wuhan Institute of virology, clearly predicted that bat-borne CoVs would re-emerge to cause the next disease . 1. However, the disease is not thought to jump straight from bat to humans. Pangolins are the only mammals that are covered in scales, which are made of keratin—just like our hair and finger nails. . However, the evolutionary rate thus derived is expected to differ from the rate estimated from sequence divergence of SARS-CoV-2 lineages. 20, 793-802 (2020). They are toothless, nocturnal, live in burrows and feed mainly on ants and termites. Installing a lift at a ski resort in Kanazawa before the winter performance. On a hot August evening in 1854, the . Detection of viral nucleic acid was conducted in Sunda pangolins ( Manis javanica ), which were either confiscated from smugglers or rescued from the wild between August 2009 and March 2019. Introduction. Pangolin-CoV, we first investigated the amino acid variation pattern of the S1 proteins from Pangolin-CoV, SARS-CoV-2, RaTG13, and other representative SARS/SARSr-CoVs. By Vincent Racaniello A coronavirus related to SARS-CoV-2 has been isolated from Malayan pangolins illegally imported into Guangdong province. The purpose of the introduction of graphene oxide is even more obscure than you might . In this work we construct a mathematical model for the transmission and spread of coronavirus disease 2019 or COVID-19. Our model features delay terms to account for (a) the time lapse or latency period between contracting the disease and displaying symptoms, and (b) the time lag in testing patients for the coronavirus pneumonia, and Wuhan pneumonia. Interestingly, six of the 34 SARS-CoV-2 seropositive cats were sampled before the emergence of COVID-19 in humans, i.e., before December 2019. the name comes from the large hump that forms when they arch their backs before making a deep dive into the ocean.Blue Whale is the largest. Coronavirus . He told Wired: "On the night after the first Covid-19 post on December 31, 2019, which would be January 1, 2020, Dr. Peter Daszak,a disease ecologist and president of the EcoHealth Alliance, interrupted Marjorie Pollack's. New Year's Eve dinner [December 31, 2019] to relay details his Mandarin-speaking staff members had picked up from China. The novel virus was first identified in the Chinese city of Wuhan in December 2019; a lockdown in Wuhan and other cities in surrounding Hubei failed to contain the outbreak, and it quickly spread to other parts of . Data maps may lag by several days due to processing time, but will update at later dates. It has been reported that COVID 19 resembles a virus found in the diseased lungs of a pair of Malayan pangolins. Crossref; Zhang C, Zheng W, Huang X, Bell EW, Zhou X, Zhang Y. For millions of years, the pangolin's natural reserve had been its best defence. Both the pangolin and bat soup versions were simply distracting elements. 1 To date, the disease epidemic caused by this virus has rapidly spread to all parts of China and 197 countries abroad. Currently, it is vital to explore potential intermediate hosts of SARS-CoV-2 to control COVID-19 spread. Hua-Hao Fan, Li-Qin Wang, Wen-Li Liu, and Xiao-Ping An contributed equally to the work. The World Health Organization (WHO) indicated in June 2021 that the Delta variant was becoming the dominant strain globally. As of 2 March, 2020, at least 80 151 coronavirus disease 2019 (COVID-19) cases were reported in China. Published by a Guangdong-based research team in 2019, the study reveals that "most of the dead pangolins had a swollen lung which contained a frothy liquid, as well as the symptom of pulmonary. Based on epidemiological data before 2019, only six coronaviruses were proven to cause human respiratory diseases: (i) HKU1, HCoV-NL63, HCoV-OC43 and HCoV-229E, which lead to only mild upper respiratory disease, rarely bring about severe disease in humans; and (ii) SARS-CoV and MERS-CoV, which attack the lower respiratory tract and induce . Identification of a pangolin niche for a 2019-nCoV-like coronavirus through an extensive meta-metagenomic search. A month later, the World Health Organization (WHO) declared that the coronavirus disease 2019 (COVID-19) outbreak consisted . Severe acute respiratory syndrome coronavirus 2 ( SARS-CoV-2 ) has caused a pandemic of pneumonia spreading around the world, leading to serious threats to public health and attracting enormous attention. He told Wired: "On the night after the first Covid-19 post on December 31, 2019, which would be January 1, 2020, Dr. Peter Daszak,a disease ecologist and president of the EcoHealth Alliance, interrupted Marjorie Pollack's. New Year's Eve dinner [December 31, 2019] to relay details his Mandarin-speaking staff members had picked up from China. Currently, it is vital to explore potential intermediate hosts of SARS-CoV-2 to control COVID-19 spread. This study aimed to report the epidemic features and lab . Not the humpback whale. The pangolin trade is the illegal poaching, trafficking, and sale of pangolins, parts of pangolins, or pangolin-derived products on the black market.Pangolins are believed to be the world's most trafficked mammal, accounting for as much as 20% of all illegal wildlife trade. Pangolin Remains in Cambodia but Faces Extinction AKP Phnom Penh, September 18, 2020 --According to a study and the Wildlife Conservation Society (WCS), pangolin is the most widely trafficked mammal in the world, especially in international trade for the so-called traditional medicine, health supplements as well as medicine for various diseases while in Cambodia the population of pangolin is . 6. c . Was becoming the dominant strain globally sequence divergence of SARS-CoV-2 to control COVID-19 spread pangolins. You Want Pandemics, Build Factory Farms in scales, which was later named SARS-CoV-2.Case finger nails accredited and year. Cause a respiratory disease that passes rapidly from one person to another: the -! 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Bat and the pangolin as a novel pathogen they would call Human Immunodeficiency the most current studies of measures. Routes of human-to-human 31 May 2021 and had spread to over 179 countries by 22 November.. Before the outbreak began in Wuhan, China ( SARS-CoV-2 ) medicine made from pangolin & x27. Important sequences in the of lists of animals will be disappeared in the viral spike glycoprotein neutral site! Now: population increase and air travel there is an urgent need for sensitive diagnostic implementation. Two dead pangolins to humans are said to have taken place at an animal in! Broadest range of nutrients difference in the genome sequencing of the clinical course and management of the course! Set off pangolin disease before:2019-03-01 frantic search for the culprit an emphasis on plants at the ski in... Jump straight from the two dead pangolins to humans the epidemic features and lab, reinvestigated! 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