Betaine is a methyl derivative of glycine first isolated from sugar beets. 05 December, 2018 . Phytother Res. Should betaine be taken on an empty stomach? A randomized clinical trial of berberine hydrochloride in patients with diarrhea-predominant irritable bowel syndrome. Betaine Hcl, also known as Betaine Hydrochloride, is used to help improve digestion, yet for some it seems to cause side effects. Other side effects include insomnia, sleepiness, dry … Find everything you need to know about Betaine (Cystadane), including what it is used for, warnings, reviews, side effects, and interactions. I have had some ongoing issues, and my sister, the wellness guru, … Betaine consumed from food sources and through dietary supplements presents similar bioavailability and is metabolized to di-methylglycine and sarcosine in the liver. Betaine Hydrochloride Side Effects. Betaine HCI is thought to increase the concentration of hydrochloric acid in the stomach, which is the acid that must be present in order to break down foods and use nutrients. A large enough dose of betaine HCl will cause heartburn, so the anhydrous form is a better option for performance enhancement. However, a visit to most mainstream medical websites will advise you, “Do not take Betaine HCL”. Betaine hydrochloride is a chemical substance made in a laboratory.It is used as medicine. Dear Dr. Roach: I started taking betaine hydrochloride for my digestive health. Hello everyone, I would like to know if anyone has been taking Betaine HCl with Pepsin. In fact a common side effect is digestive problems, including stomach ache, reflux, and gas. Betaine hydrochloride has an interesting history. The ergogenic and clinical effects of betaine have been in … Betaine, also called trimethylglycine or TMG, is a naturally occurring crystalline alkaloid present in food sources like sugar beets, wheat, quinoa, and spinach. This is likely due to the rare occurrence of stomach distress that may occur after ingesting betaine anhydrous; it is actually absorbed fine with or without a meal. Betaine hydrochloride is a compound made from betaine and hydrochloric acid. Betaine hydrochloride used to be included in over-the-counter products as a "stomach acidifier and digestive aid." 2015 Nov;29(11):1822-7. doi: 10.1002/ptr.5475. I recently started taking this supplement along with DGL licorice, ginger capsules, digestive enzymes, and a probiotic. View abstract. Written by Janet Renee . In certain groups of people who have low stomach acid, they can experience a range of digestive problems that betaine may be able to help relieve . 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