The safety of Interceptor Plus has not been evaluated in dogs used for breeding or in lactating females. Safety studies in pregnant dogs demonstrated that doses of 0.6X the maximum exposure dose of INTERCEPTOR PLUS, (1.5 mg/kg of milbemycin oxime), administered daily from mating through weaning, resulted in measurable concentrations of milbemycin oxime in milk. Available in 4 different dosing sizes, making it easier to treat dogs of many different sizes with one chew. Owners of dogs living in areas where E. multilocularis or E. granulosus are endemic should be instructed on how to minimize their risk of exposure to these parasites, as well as their dog’s risk of exposure. Nerve cells in the brain pass signals among themselves using both electrical current and chemicals Thank you. Treatment with fewer than 6 monthly doses after the last exposure to mosquitoes may not provide complete heartworm prevention (see EFFECTIVENESS). One dosage of interceptor is a course that has to be taken three to six times a day. Lethargy was observed in all groups. Because the prepatent period for E. multilocularis may be as short as 26 days, dogs treated at the labeled monthly intervals may become reinfected and shed eggs between treatments. INTERCEPTOR PLUS may be administered year-round without interruption. Prior to administration of Interceptor Plus, dogs should be tested for existing heartworm infections. Clonic seizures cause the body to shake and jerk like a tonic-clonic seizure, but you do not go stiff at the start. Vomiting was only observed in the 5X treatment group on most, but not all, treatment days. Unrelated to any other anti-seizure drug, Zonisamide is an anticonvulsant drug that works as an initial epilepsy treatment or as an adjunct for hard-to-control seizure conditions. Interceptor is a prescription drug, which if given inappropriately can cause severe side effects. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the US product label or package insert. In response to your question, Milbemycin is not known to cause seizures in dogs. For complete safety information, please see Interceptor Plus product label or ask your veterinarian. Side effects of VNS include a hoarse voice, a sore throat and a cough when the device is activated. Information for Owner or Person Treating Animal: Echinococcus multilocularis and Echinococcus granulosus are tapeworms found in wild canids and domestic dogs. Test for heartworm disease before using Interceptor.In a small percentage of milbemycin-treated dogs, digestive and neurologic side effects may occur. For both lethargy and ataxia the incidence and duration increased in the 3X and 5X groups. Anne, there are no interactions that I’m aware of between Interceptor Plus and Bravecto. I started giving my Chihuahua (5 lb.) These effects were all transient and puppies returned to normal within 24 to 48 hours. It has been known to cause problems in Collie breeds but those side effects, likely, may not appear in your Poms (again ask the Vet about these side effects). Each chewable flavored tablet is formulated to provide a minimum of 0.23 mg/pound (0.5 mg/kg) of milbemycin oxime and 2.28 mg/pound (5 mg/kg) of praziquantel.Milbemycin oxime consists of the oxime derivatives of 5-didehydromilbemycins in the ratio of approxi… Possible Side Effects: All seizure control medications have potential to cause drowsiness. Heartguard Plus has a different active ingredient. Many vets also don’t report, and owners often don’t recognize side effects too. Manufactured for: Elanco US Inc., Greenfield, IN 46140, USA. Some nursing puppies, at 2, 4, and 6 weeks of age, administered oral doses of 9.6 mg/kg milbemycin oxime (3.8X the maximum exposure dose of INTERCEPTOR PLUS) exhibited tremors, vocalization, and ataxia. Diagnosing the cause of seizures may include urinalysis, CBC, Chemistry Profile plus serum cholinesterase and serum bile acid concentrations, heartworm and internal parasite tests, plus chest and abdominal radiographs if there are any suspicious findings and in dogs over six years of age. What Side Effects Might Occur with Interceptor Plus? At the discretion of the veterinarian, infected dogs should be treated to remove adult heartworms. Do not use in dogs or puppies less than two pounds of body weight. Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. The following adverse reactions have been reported in dogs after administration of milbemycin oxime or praziquantel: vomiting, diarrhea, depression/lethargy, ataxia, anorexia, convulsions, weakness, and salivation. INTERCEPTOR PLUS is available in four strengths in color-coded packages for oral administration to dogs and puppies according to their weight. Find out how monthly Interceptor Plus provides effective, year-round heartworm disease protection. INTERCEPTOR PLUS is available in four strengths in color-coded packages for oral administration to dogs and puppies according to their weight. A study, in which pregnant females were dosed once, at 0.6X the maximum exposure dose of INTERCEPTOR PLUS before, on the day of, or shortly after whelping, resulted in no effects on the puppies. So the true number of side effects is very likely to be much higher. The safety of INTERCEPTOR PLUS has not been evaluated in dogs used for breeding or in lactating females. Care should be taken that the dog consumes the complete dose, and treated animals should be observed for a few minutes after administration to ensure that no part of the dose is lost or rejected. Ataxia, lethargy, and salivation were seen in the 3X and 5X treated dogs following each of the seven doses. You'll probably still need to take AEDs. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. INTERCEPTOR PLUS is not effective against adult D. immitis. Sentinel’s side effects include vomiting, lethargy, diarrhea, urticaria, anorexia, convulsions, and more. There are no known contraindications to the use of INTERCEPTOR PLUS. The following adverse reactions have been reported in dogs after administration of milbemycin oxime or praziquantel: vomiting, diarrhea, decreased activity, incoordination, weight loss, convulsions, weakness, and salivation. In a well-controlled laboratory study, INTERCEPTOR PLUS was 100% effective against induced heartworm infections when administered once monthly for 6 consecutive months. And when they were first released, the recognized side effects really were diarrhea, vomiting, drooling and inappetence, but over time it's become apparent that there are very rare instances of muscle tremors, wobbliness and even seizures in dogs taking these drugs.  ©2020 Elanco. To report suspected adverse events, for technical assistance or to obtain a copy of the Safety Data Sheet (SDS), contact Elanco US, Inc. at 1-888-545-5973. Tonic seizures. Mary Straus October 26, 2019 at 2:57 pm. Discover how effective Interceptor Plus is at protecting dogs against worms. We comply with the HONcode standard for trustworthy health information -, Warnings and cautions for Interceptor Plus, Direction and dosage information for Interceptor Plus. Chewables may be broken into pieces and fed to dogs that normally swallow treats whole. The following adverse reactions have been reported in dogs after administration of milbemycin oxime or praziquantel: vomiting, diarrhea, depression/lethargy, ataxia, anorexia, convulsions, weakness, and salivation. No effects were observed in puppies administered 0.5 mg/kg milbemycin oxime (minimum label dose). These symptoms along with other signs like vomiting, diarrhea and … E. multilocularis and E. granulosus can infect humans and cause serious disease (alveolar hydatid disease and hydatid disease, respectively). Up to 50 out of 100 people with epilepsy report bothersome side effects of seizure medications. Each box contains stick-on labels for your calendar, making reliable, year-round protection easy to remember with a monthly reminder. Do not use in puppies less than six weeks of age. Indications: Interceptor Flavor Tabs are indicated for use in the prevention of heartworm disease caused by Dirofilaria immitis, the control of adult Ancylostoma caninum (hookworm), and the removal and control of adult Toxocara canis and Toxascaris leonina (roundworms) and Trichuris vulpis (whipworm) infections in dogs and in puppies four weeks of age or greater and two … Precautions When Giving Interceptor to a Dog Interceptor is a prescription drug, which if given inappropriately can cause severe side effects. For INTERCEPTOR PLUS the maximum exposure based on product dosing is 2.5 mg/kg for milbemycin oxime and 25.1 mg/kg for praziquantel, which is higher than the minimum effective dose used in the safety studies for milbemycin oxime (see below). (Fisher et al, 2000) Factors that May Improve the Chance of Being Seizure Free. Administer the appropriate combination of chewables. This year we were given Interceptor Plus. ... Possible side effects of Levetiracetam include drowsiness, changes in behavior, vomiting, or diarrhea. In a repeated dose safety study, 40 ten-week-old puppies (10 per group) were dosed with either a sham dose (0X) or 1, 3, or 5X the maximum label exposure of INTERCEPTOR PLUS every 14 days for a total of seven treatments. In well-controlled laboratory studies, neither one dose nor two consecutive doses of INTERCEPTOR PLUS provided 100% effectiveness against induced heartworm infections. For animals approximately only 1 % of all the side effects is being reported. The tablets containing 2.3 mg milbemycin oxime/22.8 mg praziquantel or 5.75 mg milbemycin oxime/57 mg praziquantel are also available in color coded packages of one chewable tablet each. For human medication approximately only 10 % of the side effects is being reported. Seizures, epilepsy and brain tumours. The chewables should be administered in a manner that encourages the dog to chew, rather than to swallow without chewing. Each strength is available in color-coded packages of six or twelve chewable tablets each. Store at room temperature, between 59° and 77°F (15-25°C). Milbemycin oxime and praziquantel are the two active ingredients in Interceptor Plus. Interceptor Plus comes in the form of an easy-to-administer chewable tablet that is given to dogs once monthly to prevent heartworms and intestinal parasites. These symptoms along with other signs like vomiting, diarrhea and depression are … Studies have been performed with milbemycin oxime alone (see ANIMAL SAFETY). If your dog starts drooling or suffering from seizures, you must call for emergency medical help. Each chewable flavored tablet is formulated to provide a minimum of 0.23 mg/pound (0.5 mg/kg) of milbemycin oxime and 2.28 mg/pound (5 mg/kg) of praziquantel. Your veterinarian can tell you how it prevents heartworm disease and treats and controls adult hookworm, roundworm, whipworm and tapeworm infections in dogs and puppies 6 weeks or older and 2 pounds or greater. It is just one of the many side effects; vomiting, depression, lethargy, itchiness, hives, diarrhea, weight loss, poor coordination, seizures, hypersalivation, and weakness. PM-US-19-1932. They offer protection against the five most common worms - whipworms, roundworms, hookworms, tapeworms, and heartworms. In isolated cases, however, dogs displayed more serious reactions such as tremors, muscle twitching, and … Does Interceptor plus have any side effects Asked by: Bugs The following adverse reactions have been reported in dogs after administration of milbemycin oxime or praziquantel: vomiting, diarrhea, depression/lethargy, ataxia, weight loss, convulsions, weakness, and salivation. The only thing left to treat the lungworm that I know of is Interceptor plus. Because the medications have similar ingredients, they have several similar side effects. The object of treatment is to prevent the occurrence of seizures by maintaining an effective dose of one or more antiepileptic drugs. Do know anything else that would work or think the interceptor … Two studies were conducted in heartworm-infected dogs treated with milbemycin oxime. Interceptor Plus prevents heartworm disease and controls hookworm, roundworm, whipworm, and tapeworm threats for a full month to help give you peace of mind on all your adventures. Interceptor® can safely be used in dogs starting at 4 weeks of age and cats starting at 6 weeks of age. There is no correlation between using Interceptor (generically known as milbemycin oxime) for the prevention of heartworm and seizures. These reactions are presumably caused by release of protein from dead or dying microfilariae. No seizures since and an internal medicine vet said seizures were due to the Moxidectin. With Interceptor Plus, you get protection against 5 types of worms compared with 3 types of worms with Heartgard® Plus. The safety of Interceptor Plus has not been evaluated in dogs used for breeding or in lactating females. INTERCEPTOR PLUS may be offered to the dog by hand or added to a small amount of dog food. I did a search on the web about Interceptor and Heartguard looking for the related side effects.They must keep this information closely guarded.I couldn't find much at all about the subject.The only information I was able to find was on question and answer boards like this one.It should be of special interest to you.It … Would a lower dosage be effective and cause less or/no side effects. Prior to receiving the 12.5 mg/kg dose on day 56 of the study, all animals had undergone a dosing regimen consisting of 2.5 mg/kg milbemycin oxime on day 0, followed by 5.0 mg/kg on day 14, and 10.0 mg/kg on day 32. That’s more types of worms than Heartgard® Plus (ivermectin/pyrantel). Bravecto side effects. When switching from another heartworm preventative product to INTERCEPTOR PLUS, the first dose of INTERCEPTOR PLUS should be given within a month of the last dose of the former product. It is killing my older collie. The following adverse … VNS does not usually stop seizures completely, but it can help make them less severe and less frequent. The labels of such products already include information about the risk of neurological side effects, the network reports. At the discretion of the veterinarian, infected dogs should be treated to remove adult heartworms. They often will go away over several … Most seizures last from 30 seconds … Interceptor Plus is approved for use in dogs and puppies 2 pounds of body weight or greater and 6 weeks of age and older. Elimination of the adult stage of hookworm (A. caninum), roundworm (T. canis, T. leonina), whipworm (T. vulpis) and tapeworm (T. pisiformis, E. multilocularis, E. granulosus and D. caninum) infections in dogs was demonstrated in well-controlled laboratory studies. A positive response means that seizures do not recur and the person is seizure … Since she has never taken meds, I am concerned about the side effects of Interceptor Plus. What are the Active Ingredients in Interceptor Plus? Are you tired of trying to find the best anti-parasite treatment for dogs? Intestinal Nematodes and Cestodes Treatment and Control: Elimination of the adult stage of hookworm (Ancylostoma caninum), roundworm (Toxocara canis, Toxascaris leonina), whipworm (Trichuris vulpis) and tapeworm (Echinococcus multilocularis, Echinococcus granulosus, Taenia pisiformis and Dipylidium caninum) infections in dogs was demonstrated in well-controlled laboratory studies. Interceptor Plus delivers parasite protection with milbemycin oxime and praziquantel, the active ingredients in the product. When you choose Interceptor Plus, you’ll enjoy a number of benefits with one monthly chewable tablet. Interceptor Plus is only available with a prescription from your veterinarian. These reactions are presumably caused by release of protein from dead or dying microfilariae. Intestinal Nematode and Cestode Treatment and Control: Dogs may be exposed to and can become infected with roundworms, whipworms, hookworms, and tapeworms throughout the year, regardless of season or climate. You should discuss the use of Interceptor Plus with your veterinarian prior to use if your dog has a history of epilepsy (seizures). INTERCEPTOR PLUS is indicated for the prevention of heartworm disease caused by Dirofilaria immitis; and for the treatment and control of adult roundworm (Toxocara canis, Toxascaris leonina), adult hookworm (Ancylostoma caninum), adult whipworm (Trichuris vulpis), and adult tapeworm (Taenia pisiformis, Echinococcus multilocularis, Echinococcus granulosus, and Dipylidium caninum) infections in dogs and puppies two pounds of body weight or greater and six weeks of age and older. Prior to administration of INTERCEPTOR PLUS, dogs should be tested for existing heartworm infections. Because the prepatent period for E. multilocularis may be as short as 26 days, dogs treated at the labeled monthly intervals may become reinfected and shed eggs between treatments. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. These signs were observed during the first 24 hours following treatment. Reply. Interceptor Plus has been demonstrated to be safe in healthy dogs when given according to labeled directions. Seizure types vary by where and how they begin in the brain. Milbemycin oxime consists of the oxime derivatives of 5-didehydromilbemycins in the ratio of approximately 80% A4 (C32H45NO7, MW 555.71) and 20% A3 (C31H43NO7, MW 541.68). Drug safety studies performed before releasing the drug showed no significant side effects of any kind in dogs who received the heartworm prevention dose for that purpose. At … That may sound like a lot, but it's important to remember that not everybody who is affected by a brain tumour will experience seizures or epilepsy. PM-US-19-1932, ©2020 Elanco. If you have two or more seizures or a tendency to have recurrent seizures, you have epilepsy.There are many types of seizures, which range in severity. Side Effects and Drug Reactions. In case overdose does occur, the person has to be taken immediately to the hospital for a stomach wash without … The safety of Interceptor Plus has not been evaluated in dogs used for breeding or in lactating females. Interceptor’s side effects include vomiting, lethargy, ataxia, weakness, hyper-salivation, and a few others. Every effort has been made to ensure the accuracy of the Interceptor Plus information published above. Updated: 2021-01-29. Also, often times it is a little cheaper than Interceptor. INTERCEPTOR PLUS is available in four strengths, formulated according to the weight of the dog. Interceptor, Credelio, Elanco and the diagonal bar logo are trademarks of Elanco or its affiliates. Interceptor Plus's common adverse reactions reported are vomiting, diarrhea, depression, lethargy, ataxia, hypersalivation, seizures, weakness, and decreased appetite. Parasites in dogs are no laughing matter, in fact, many dog owners absolutely shrivel at the thought of creepy parasites infesting their pets. They typically last a few minutes and you might lose consciousness. A rising-dose safety study conducted in rough-coated Collies resulted in ataxia, pyrexia, and periodic recumbency in one of fourteen dogs administered milbemycin oxime at 12.5 mg/kg (5X the maximum exposure dose of INTERCEPTOR PLUS). Salivation and tremors were observed in the 3X and 5X treated dogs beginning immediately after dosing and up to six hours post dose. Cautions: Keep away from children. Vomiting was seen in all treatment groups but had a higher incidence in the 3X and 5X treatment groups. Some of these may not occur or are tolerated okay if the medication is started at a low dose and increased slowly. INTERCEPTOR PLUS should be administered orally, once every month, at the minimum dosage of 0.23 mg/lb (0.5 mg/kg) milbemycin oxime, and 2.28 mg/lb (5 mg/kg) praziquantel. Zonisamide is a sulfonamide anti-seizure medication. Isoxazoline products have been associated with neurologic adverse reactions, including muscle tremors, ataxia, and seizures in some dogs and cats; We didn’t notice much right away except for some lethargy and a lot of loose stools. Your dog is doing an atypical form of seizure activity called fly bitting. INTERCEPTOR PLUS should be administered at monthly intervals beginning within 1 month of the dog’s first seasonal exposure to mosquitoes and continuing until at least 6 months after the dog’s last seasonal exposure (see EFFECTIVENESS). No adverse reactions were observed in any of the Collies treated with doses less than 12.5 mg/kg. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or http://www.fda.gov/reportanimalae. Mild, transient hypersensitivity reactions, such as labored breathing, vomiting, hypersalivation, and lethargy, have been noted in some dogs treated with milbemycin oxime carrying a high number of circulating microfilariae. Interceptor Side Effects in Dogs Every drug that your dog might take often has the possibility that there will be side effects when your dog takes it. Praziquantel is an isoquinolone anthelmintic with the chemical name 2-(Cyclohexylcarbonyl)-1,2,3,6,7,-11b-hexahydro-4H-pyrazino [2,1-a]isoquinolin-4-one. An interceptor comes in the form of a tablet or tonic. Is at protecting dogs against worms cause less or/no side effects, network. To mosquitoes ( see ANIMAL safety ) adult D. immitis appropriate measures to prevent the occurrence of seizures by an... 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